Isoxazolyl Penicillins - The Veterinary Site

Isoxazolyl Penicillins


Isoxazolyl Penicillins
These are also called as β-lactam antibiotics. These are:
1)      Cloxacillin
2)      Dicloxacillin
3)      Oxacillin

Ü  These are semi-synthetic penicillins
Ü  These are also stable in acidic pH. So, these can be given orally.
Ü  These show very good resistance against Penicillinase/β-lactamase
Ü  These are effective against Staphylococcus aureus
Ü  These are excreted through faeces
Nafcillin
Ø  It is also semi-synthetic antibiotic against Staphylococcus aureus
Ø  It is easily hydrolyzed by Pencillinase/β-lactamase just like Aminopenicillins
Ø  It is administered I/M and orally
Ø  Its gastric absorption is invariable
Ø  Nafcillin 90% binds with the plasma protein i.e. albumen and then distributed

    Don’t administer 5% dextrose with barbiturates
    Give steroid + anti-histaminic injection (Dexamethasone + Avil) in last stage of milk fever to save the animal from dying
Adverse Reaction of Penicillins
1)      Hypersensitivity type 1, 2
·         Often encountered with the use of penicillins
·         Penicillanic acid conjugates with Heptans (proteins) of the body => Got antigenic activity as present in any pathogen => P-H conjugate in hypersensitive animal
o Muco-purulent rashes
o Angioedema (swelling of the dermis) on lips, tongue and peri-orbital area
o Neurotoxicity of membrane in case of intra-thecal hypersensitivity
2)      Diarrhea
3)      Intestinal nephritis
4)      Carbenicillin, member of carboxypenicillin subgroup of penicillin, decreases the blood agglutination


Isoxazolyl Penicillins Isoxazolyl Penicillins Reviewed by Maaz ahmed siddiqui on 09 May Rating: 5

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