Do you know about Anti-Parasitic Drugs ? - The Veterinary Site

Do you know about Anti-Parasitic Drugs ?


Anti-Parasitic Drugs

(by MAAZ AHMED SIDDIQUI)

There is a long category of parasitic infections and also anti-parasitic drugs. Some books say that repeat the deworming after 3 months and some say that after 4 months. There should be rotational use of drugs throughout the year. Following are some important groups of anti-parasitic drugs:
1.      Benzimidazoles
2.      Probenzimidazoles
These are effective against:
ü  Habronema
ü  Gasterophilus
ü  Strongylus
ü  Dictyocaulus
ü  Ostertagia
ü  Oncocera
ü  Trichuris

1.  Benzimidazoles
This group contains following important drugs:
1)      Thiabendazole
·         66-110 mg/kg
2)      Albendazole
·         7.5 mg/kg in cow
·         5 mg/kg in sheep and goat
3)      Febendazole
4)      Oxfendazole
·         4.5 mg/kg in cow
·         5 mg/kg in sheep and goat
5)      Cambendazole
6)      Mebendazole
·         Pale to yellowish colour
·         8 mg/kg in horse
·         15 mg/kg in sheep and goat
7)      Oxibendazole
·         10 mg/kg in sheep and goat
·         50 mg/kg in horse
8)      Flubendazole
·         It is not usually used
9)      Parbendazole
10)  Ricobendazole
Albendazole, Oxfendazole and Mebendazole are most commonly used anti-parasitic drugs. Oxfendazole, Cambendazole, Flubendazole and Parbendazole are white crystalline powder. Above mentioned drugs are also used in combinations to broad their spectrum against parasites.
These have 1, 2-diaminobenzin in their structure. These are slightly soluble in water but soluble in alcohol and other organic solvents. These are mostly aqueous preparations (suspensions). These have limited absorption through gut. These are commonly used in gout.
Plasma level is not more than 1% of the abdominal dose means that if you administer 1000mg drug, 10mg will be the level achieved in blood.
Presence of food decreases their bioavailability. These are excreted through urine and faeces.
 Mode of Action
Parasites are multicellular. Cells contain microtubules which give texture to the cells and also involved in spindle formation during cell division. These are made of tubulin protein.
Basically benzimidazoles inhibit the polymerization of b-tubulin. These bind with the b-tubulin which results in no diagnosing and polymerization of b-tubulin and thus there will be no formation of microtubules and the cells will be destroyed ultimately causing death of the parasite.
«  As benzimidazoles are used in animals, Colchicine is used in human having same function. Benzimidazoles don’t inhibit the polymerization of b-tubulin in mammalian cell.
«  Ever best dewormer is Oxanid (oxfendazole + oxazepam)
«  Levamisole is anti-parasitic as well as immune mediator but it is contraindicated in equines.
Toxicity
Their toxicity is quite low. Their dose is well tolerated in the body.
Problems
The main problem associated with them is that these are teratogenic.
2.  Probenzimidazoles
This group contains two important anti-parasitic drugs:
1)      Netobium
2)      Febental
Netobium is mostly used while Febental is somehow used. These are not commonly used. Their mode of action is same to benzimidazoles.


Do you know about Anti-Parasitic Drugs ? Do you know about Anti-Parasitic Drugs ? Reviewed by Maaz ahmed siddiqui on 23 May Rating: 5

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